Case Studies


Published: June 2009
Author: Jerry Fireman

Rich Products used DOE to develop an all-natural bread dough that would met the same quality and taste standards as their popular conventional bread doughs.

Publication: Food Quality magazine

Published: February 2009
Author: Jeff Falk

Alberto-Culver developed a new line of scrubs using design of experiments (DOE) that far exceeds the performance of what they thought was possible.

Publication: Global Cosmetic Industry

Published: January 2009
Authors: Mark Anderson, Zivorad Lazic

A statistically based design of experiments (DOE) approach developed specifically for mixtures was used to formulate a blend of rayon fibers that produced maximal tampon absorbency.

Published: January 2009
Author: DiaSorin Inc.

Diasorin recently used DOE to evaluate the robustness of its process for manufacturing an alpha-1-antitrypsin (AAT) assay.

Published: January 2009
Authors: B. Imperatore, A. Marino, A. Ragini

An experimental investigation was carried out in the PT-1 in order to determine the best porosity distribution in order to maximize the reduction of the wall interference over the widest possible Mach number range. Over 360 test points were measured on different models and wall porosity configurations over the selected mach number range to find out the minimum interference configuration for the PT-1; however, as these results are not wind tunnel-specific, they are expected to be applicable to all similar facilities. The optimum porosity distribution has been achieved trough an experiment designed with a Modern Design Of Experiment (MDOE) approach.

Publication: American Institute of Aeronautics and Astronautics

Published: December 2008
Author: Craig Stolarczyk

The Williamette Valley Co. (WVCO) increased manufacturing yield by designing an experiment to simultaneously measure the impact of key factors on critical responses.

Publication: Quality Magazine

Published: October 2008
Author: Mark Anderson

Engineers at a major medical device manufacturer used RSM to successfully model a key process for their flagship product. The RSM model then became the foundation for development of robust specifications to ensure quality at six sigma levels.

Lean Six Meets Foil Stamping

Published: October 2008
Author: Reed Wahlberg

A large printing company tasked a Lean Six Sigma project team with finding a way to reduce setup time and costs in a department consisting of 33 Kluge presses. The results of the DOE led to a reduction of 5% in printing costs by moving to a less expensive foil for that job, and other knowledge gained from the experiment led to a 40% reduction in setup time over the last two years.

Publication: Graphic Arts Online

Published: September 2008
Author: Mark Anderson

A custom rubber molder used DOE to uncover a combination of material selection and manufacturing protocol that created unacceptable results. Armed with this process knowledge, they achieved a breakthrough quality improvements.

Publication: Rubber & Plastics News

Automated Enzyme Assay Design and Optimization

Published: September 2008
Authors: James Batchelor, Laurel Provencher, Abbie Estermann, Seth Cohen

This poster displays the abstract and results of an experiment done to optimize enzymatic assays. Experimenters tested buffer, detergent, salt, and cation combinations using a 384-well microtiter plate format. The presence of different detergents and their interactions with different buffers had a profound effect on the enzyme turnover.

Publication: Caliper LifeSciences (now PerkinElmer)