Case Studies and White Papers


Design of Experiments Helps Improve the Robustness of Off-Highway Vehicle Coating

Published: July 2009
Author: Henkel Corp.

An agricultural equipment manufacturer asked Henkel to help optimize a tough coating application using DOE.

Publication: SAE Off-Highway Engineering

Published: June 2009
Author: Jerry Fireman

Rich Products used DOE to develop an all-natural bread dough that would met the same quality and taste standards as their popular conventional bread doughs.

Publication: Food Quality magazine

Published: June 2009
Author: Jerry Fireman

Using design of experiments, Land O'Lakes researchers set out to improve a new deli process cheese formulation, without impacting its other attributes. They achieved a significant improvement in appearance of the new without adversely affecting other characteristics.

Publication: Food Product Design (now Natural Products Insider)

Published: February 2009
Author: Jeff Falk

Via mixture design of experiments (DOE) Alberto-Culver developed a new line of scrubs that far exceeded the performance of what they thought was possible. The formulator said "We selected Design-Expert software from Stat-Ease because of its exceptional capabilities in the design and analysis of mixture experiments. The end result is that we can get products to market faster and at a lower cost than with conventional experiment designs."

Publication: Global Cosmetic Industry

Published: January 2009
Authors: Mark Anderson, Zivorad Lazic

A statistically based design of experiments (DOE) approach developed specifically for mixtures was used to formulate a blend of rayon fibers that produced maximal tampon absorbency.

Design of Experiments Demonstrates Robustness of Biopharmaceutical Process

Published: January 2009
Author: Mark Anderson

Diasorin used DOE to evaluate the robustness of its process for manufacturing an alpha-1-antitrypsin (AAT) assay. The results provided a considerable degree of confidence that existing in-process quality control criteria sufficed for being assured of meeting finished product requirements. This case study provides an excellent example of how DOE can reduce the time required to perform a latitude study while delivering statistical analysis that increases the degree of confidence in the study.

Published: December 2008
Author: Craig Stolarczyk

The Williamette Valley Co. (WVCO) increased manufacturing yield by designing an experiment to simultaneously measure the impact of key factors on critical responses.

Publication: Quality Magazine

Lean Six Meets Foil Stamping

Published: October 2008
Author: Reed Wahlberg

A large printing company tasked a Lean Six Sigma project team with finding a way to reduce setup time and costs in a department consisting of 33 Kluge presses. The results of the DOE led to a reduction of 5% in printing costs by moving to a less expensive foil for that job, and other knowledge gained from the experiment led to a 40% reduction in setup time over the last two years.

Publication: Graphic Arts Online

Published: October 2008
Author: Mark Anderson

Engineers at a major medical device manufacturer used RSM to successfully model a key process for their flagship product. The RSM model then became the foundation for development of robust specifications to ensure quality at six sigma levels.

Optimizing Design of Experiments for Fluid Bed Coating

Published: September 2008

Upsher-Smith Laboratories used response surface methods (RSM) to optimize a fluid bed coating process that was producing inconsistent results. Aided by Design-Expert software, scientists discovered a most desirable setup that gave consistent results within specifications with little variability. When transferred to production, the new setup provided excellent results.

Publication: Pharma QbD