New Distance Learning Options

Learn design of experiments (DOE) from your own desk! Take advantage of Stat‑Ease's premium offerings that blend eLearning, books, and live, instructor-led sessions.

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Design of Experiments Workshops

We offer hands-on design of experiments workshops, both in the United States and abroad. Whether you are looking for a class for the first-time experimenter or the advanced practitioner, we can help.

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Design-Expert Software

Whether you are new to design of experiments or a seasoned pro, you'll make breakthrough improvements to a product or a process with Design‑Expert software. Now on macOS.

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2020 Online DOE Summit

Improve your DOE knowledge and skill set with these free webinars. Register now!

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A better product. An improved process. Stat-Ease, armed with an expertise in design of experiments, has been helping people make breakthroughs since 1985. Find out how our Design‑Expert software, training, books, and consulting can help you improve your bottom line.

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Design-Expert Version 12

Design of Experiments Software

Design-Expert version 12

Make breakthrough improvements to a product or a process with Design-Expert, whether you are new to design of experiments or a pro. Its straightforward, easy-to-use interface sits on top of a powerful statistical engine. You will not only screen for vital factors, but also locate ideal process settings for top performance & discover optimal product formulations.

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Distance Learning

Learn at Home


Learn design of experiments (DOE) from your office! Stat-Ease offers new and unique ways to discover how DOE moves your business to the next level. Take advantage of Stat-Ease's premium offerings that combine eLearning, books, and live, instructor-led sessions. Register now for the distance learning program that best meets your needs!

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What's New

Case Study

Response Surface Methods Point the Way to Higher rAAV Yields at Lower Levels of Transfection Reagent

By Kara Bautista on May 13, 2020

Researchers at Adverum Biotechnologies have demonstrated that a novel multifactor design of experiments (DOE) methodology can optimize production of a recombinant adeno-associated virus (rAAV) vector. The methodology, an advanced form of DOE that incorporates response surface methods (RSMs), focused on the relative amounts of transfection agent polyethylenimine (PEI) and DNA.

This methodology is unique because of the way it keeps the ratio of PEI nitrogen to DNA phosphate—the N/P ratio—within a specified range. The N/P ratio is well known to influence the rAAV yields obtained via transient transfection.

New Blog Post

New Blog Post: Greg's DOE Adventure - Factorial Design, Part 2

By Greg on April 16, 2020

The latest installment of Greg's DOE Adventure covers more of the basic concepts behind DOE and factorial design. In this blog post, planning an experiment and randomization are covered. Discussing what each concept is and why they are so important.


Webinar: Know the SCOR for Multifactor Strategy of Experimentation

By Mark Anderson on April 20, 2020

By way of example, this presentation lays out a strategy for design of experiments (DOE) that provides maximum efficiency and effectiveness for development of a robust process. It provides a sure path for converging on the ‘sweet spot’—the most desirable combination of process parameters and product attributes. Whether you are new or experienced at doing DOE, this talk is for you (and your organization's bottom line!).