Case Studies and White Papers


PCR Process Optimized via Split-Plot DOE

Published: May 2005
Authors: Patrick Whitcomb, Shari Kraber

This paper illustrates the use of design of experiments (DOE) and split-plot design to quickly and effectively determine the factor settings that maximize amplification in a polymerase chain reaction (PCR) experiment.

Publication: 2005 ASQ World Congress

Published: April 2005
Authors: Thomas Erbach, Lisa Fan, Shari Kraber

An innovative blend of hardware, software and the right training in statistical know-how supercharges research automation.

Publication: Quality Digest

Design of Experiments Training Banishes Purple-Paper Blues

Published: April 2005
Author: Stora Enso

A paper mill used DOE to pre-define the appearance and shade of paper before full production. They discovered an unexpected interaction takes of a new blue-dye with coating formulation containing a starch binder. It turned the paper purple, which did not happen with a latex binder. This episode formed the basis for a DOE-training exercise.

Published: February 2005
Author: Stepan Co.

DOE is used in this study demonstrating the versatile compatibility of a unique polyester polyol, PD-90 LV, with both polyester and polyether polyols.

Publication: Adhesives & Sealants Industry

Published: February 2005
Author: Charles Zovko

Engineers use mixture design to create thinner, whiter keypad backlighting. A slightly different version was published in Product Design & Development.

Publication: Product Design & Development

Published: December 2004
Author: Bill Craig

Proper application of solder paste onto a PCb is essential in surface mount assemblies. In this case study DOE was used to understand this process, and ultimately to improve electrical yields.

Publication: Surface Mount Technology

Published: July 2004
Author: Carl Clarke

Engineers solved two perplexing wafer production mysteries using design of experiments (DOE), saving the company $180,000 a year.

Publication: MICRO Magazine (Discontinued)

How Experimental Design Optimizes Assay Optimization

Published: June 2004
Authors: Thomas Erbach, Lisa Fan, Shari Kraber

Optimizing biological assay conditions is a demanding process that scientists face daily. The requirement is to develop high-quality, robust assays that work across a range of biological conditions. The demand is to do this within a short time frame. To overcome these obstacles, automated assay optimization (AAO) systems often are used to accommodate large numbers of samples. Applying DOE to AAO is essential to make the best use of this high-tech equipment.

Publication: ADVANCE for Medical Laboratory Professionals

Screening Process Factors In The Presence of Interactions

Published: May 2004
Authors: Mark Anderson, Patrick Whitcomb

This article introduces a new, more efficient type of fractional two-level factorial design of experiments (DOE) tailored for the screening of process factors. These designs are referred to as Min Res IV.

Publication: AQC 2004 Toronto

Success with DOE

Published: April 2004
Author: Mark Anderson

A basic primer, taken from "DOE Simplified" text, on underlying statistics and simple forms of DOE.

Publication: Quality