Case Studies and White Papers

Published: August 2008
Author: David Gore

A major Tier 1 automotive supplier wanted to improve the already high level of quality in their manufacturing process welding nuts to a metal seat frame. They contacted Middle Tennessee State University (MTSU) and requested a design of experiments (DOE) study to determine root causes of torque failures and areas of improvement.

Publication: Quality Magazine

Published: August 2008
Author: Mark Anderson

This article demonstrates how to uncover "sweet spots" where multiple fab-process specifications can be met in a most desirable way.

Publication: Fab Engineering & Operations

Published: June 2008
Authors: Dan Cler, Jerry Fireman

Design of experiments was used for a series of computer simulations to design a new generation of muzzle brakes. DOE saves time by reducing the amount of simulations required and makes it possible to optimize the design with a higher level of certainty.

Publication: Military Embedded Systems

Published: June 2008
Author: Aerochem Inc.

Mixture DOE catalyzed development of a primer-paint remover that met the requirements of an aircraft manufacturer for environmental safety and speed. The new formulation took only 2 hours to strip off coatings, a huge improvement over competitive products that needed over 8 hours.

Publication: Aerospace Engineering & Manufacturing

Pharmaceutical Manufacturer Increases Yield with Response Surface Methods

Published: April 2008

MannKind Corporation used designed experiments to identify and optimize critical process variables involved in producing a small molecule substrate for use in pulmonary drug delivery.

Publication: Pharmaceutical Processing

Statistical Design of Experiments on Fabrication of Starch Nanoparticles - A Case Study for Application of Response Surface Methods

Published: April 2008
Authors: Nadeem Irfan Bukhari, Simran Kaur, Saringat H. Bai, Yuen Kah Hay, Abu Bakar Abdul majeed, Yeow Beng Kang, Mark Anderson

This paper details the fabrication of nanoparticles as an example for showing a statistically-rigorous approach to design and analysis of pharmaceutical experiments.

Published: April 2008
Author: Mark Anderson

In this mini-paper, Mark Anderson details an in-class experiment illustrating the power of two-level factorial design. Also learn how to shoot a wicked slap shot!

Publication: Statistics Division Newsletter

Published: March 2008
Author: Peter Jones

Researchers successfully used DOE to evaluate potential methods for removing three common endocrine disrupters. The researchers treated solutions containing the EDCs nonlyphenol (NP), bisphenol A (BPA) and triclosan (TCS) with an enzyme preparation from the white rot fungus Coriolopsis polyzona.

Publication: Environmental Science & Engineering

Applicazione di specifiche tecniche DoE per la progettazione di una macchina per il confezionamento di filtri per sigarette

Published: October 2007
Authors: Ivan Eusepi, Marco Righetti

This presentation in Italian details a DOE case study on a filter cigarette packaging machine design using Design-Expert software.

Publication: SixSigmaIn

Published: October 2007
Authors: Mark Anderson, Patrick Whitcomb

This article starts with the basics on RSM before introducing two enhancements that focus on robust operating conditions: Modeling the process variance as a function of the input factors and Propagation of error(POE) transmitted from input factor variation. It discusses how to find the find the flats high plateaus for maximum yield and broad valleys that minimize defects. Proceeding from International SEMATECH Manufacturing Initiative (ISMI) Symposium on Manufacturing Effectiveness.