Case Studies and White Papers


Automated Enzyme Assay Design and Optimization

Published: September 2008
Authors: James Batchelor, Laurel Provencher, Abbie Estermann, Seth Cohen

This poster displays the abstract and results of an experiment done to optimize enzymatic assays. Experimenters tested buffer, detergent, salt, and cation combinations using a 384-well microtiter plate format. The presence of different detergents and their interactions with different buffers had a profound effect on the enzyme turnover.

Publication: Caliper LifeSciences (now PerkinElmer)

Published: August 2008
Author: David Gore

A major Tier 1 automotive supplier wanted to improve the already high level of quality in their manufacturing process welding nuts to a metal seat frame. They contacted Middle Tennessee State University (MTSU) and requested a design of experiments (DOE) study to determine root causes of torque failures and areas of improvement.

Publication: Quality Magazine

Published: August 2008
Author: Mark Anderson

This article demonstrates how to uncover "sweet spots" where multiple fab-process specifications can be met in a most desirable way.

Publication: Fab Engineering & Operations

Published: June 2008
Authors: Dan Cler, Jerry Fireman

Design of experiments was used for a series of computer simulations to design a new generation of muzzle brakes. DOE saves time by reducing the amount of simulations required and makes it possible to optimize the design with a higher level of certainty.

Publication: Military Embedded Systems

Published: June 2008
Author: Aerochem Inc.

Mixture DOE catalyzed development of a primer-paint remover that met the requirements of an aircraft manufacturer for environmental safety and speed. The new formulation took only 2 hours to strip off coatings, a huge improvement over competitive products that needed over 8 hours.

Publication: Aerospace Engineering & Manufacturing

Pharmaceutical Manufacturer Increases Yield with Response Surface Methods

Published: April 2008

MannKind Corporation used designed experiments to identify and optimize critical process variables involved in producing a small molecule substrate for use in pulmonary drug delivery.

Publication: Pharmaceutical Processing

Published: April 2008
Author: Mark Anderson

In this mini-paper, Mark Anderson details an in-class experiment illustrating the power of two-level factorial design. Also learn how to shoot a wicked slap shot!

Publication: Statistics Division Newsletter

Statistical Design of Experiments on Fabrication of Starch Nanoparticles - A Case Study for Application of Response Surface Methods

Published: April 2008
Authors: Nadeem Irfan Bukhari, Simran Kaur, Saringat H. Bai, Yuen Kah Hay, Abu Bakar Abdul majeed, Yeow Beng Kang, Mark Anderson

This paper details the fabrication of nanoparticles as an example for showing a statistically-rigorous approach to design and analysis of pharmaceutical experiments.

Published: March 2008
Author: Peter Jones

Researchers successfully used DOE to evaluate potential methods for removing three common endocrine disrupters. The researchers treated solutions containing the EDCs nonlyphenol (NP), bisphenol A (BPA) and triclosan (TCS) with an enzyme preparation from the white rot fungus Coriolopsis polyzona.

Publication: Environmental Science & Engineering

Graphical Selection of Effects in General Factorials

Published: October 2007
Authors: Patrick Whitcomb, Gary Oehlert

This presentation details and demonstrates how to plot effects from general factorials, for example a 3x4x4, on a half-normal plot. This makes selection easy and more precise by it being a graphical method. Previously the half-normal plot of effects, developed by Cuthbert Daniel, was restricted to two-level factorials.

Publication: 2007 Fall Technical Conference