Case Studies and White Papers


Published: July 2010

Schiff Nutrition used DOE to solve an intermittent problem with a multimineral tablet sticking inside the dies of a high-speed rotary tablet press. (To see the figures, download the manuscript from link below.)

Publication: Healthcare Packaging

Published: June 2010
Authors: Mahesh Shivhare, Graham McCreath

This article details the role DOE in achieving Quality by Design (QbD) for the manufacture of active pharmaceutical ingredients (API). It features outputs from Design-Expert, the author's top choice for DOE software.

Publication: BioProcess International

Published: June 2010
Author: Dresser Waukesha

The Dresser Waukesha development team adopted the design of experiments (DOE) approach to increase the accuracy of performance estimates and reduce the number of required tests.

Publication: Power

Published: March 2010
Author: DE Editors

To accelerate their product development, Z Corporation tooled up their engineers with the knowledge and software to do statistical design of experiments (DOE). The company developed a procedure by which every factor with a reasonable chance of affecting product performance is systematically and simultaneously evaluated via these controlled experiments.

Publication: Digital Engineering

Published: March 2010
Author: Mark Anderson

To accelerate their product development, Z Corporation tooled up their engineers with the knowledge and software to do statistical design of experiments (DOE). The company developed a procedure by which every factor with a reasonable chance of affecting product performance is systematically and simultaneously evaluated via these controlled experiments.

Published: January 2010
Authors: A. Marino, R. Fauci, R. Donelli, A. Schettino

Design of Experiments was used to study the laminar-turbulence transition phenomenon in a Hypersonic regime on a 3-deg half-angle sphere-cone model.

Publication: SixSigmaIn Team

Published: January 2010
Authors: Ian Forster, Warren Dominy, Addison Lawrence, Frank Castille, Susmita Patnaik

Two five-week growth trials were conducted using mixture methodology to optimize a reference diet for Pacific white shrimp using krill meal, menhaden fishmeal, squid meal, and soy protein isolate (SPI).

Publication: Aquaculture

Published: September 2009
Authors: Drissand Elhanafi, Jim Carey

Aided by DOE, biochemists determined the statistically significant factors affecting the growth of an E. coli cell line in shaker flasks.

Publication: NCSU Bioprocessing and Process Development Symposium

Making Use of Mixture Design to Optimize Olive Oil - A Case Study

Published: August 2009
Authors: Mark Anderson, Patrick Whitcomb

Olive oil, an important commodity of the Mediterranean region and a main ingredient of their world-renowned diet (see sidebar), must meet stringent European guidelines to achieve the coveted status of "extra virgin." Oils made from single cultivars (a particular cultivated variety of the olive tree) will at times fall into the lower "virgin" category due to seasonal variation. Then it becomes advantageous to blend in one or more superior oils. This is a great case to become acquainted with the tools of mixture design for optimal formulation.

Publication: ASQ Chemical and Process Industries Division Newsletter

Design of Experiments Helps Optimize Cell Culture Bioproduction System

Published: August 2009

Invitrogen Corporation utilized response surface methods (RSM) to reveal a complicated array of multi-factor interactions involved in bioprocess development. Using advanced tools in Design-Expert, they achieved more desirable conditions in a minimal number of runs.

Publication: BioProcess International