Case Studies


Published: June 2010
Authors: Mahesh Shivhare, Graham McCreath

This article takes a look at the different things that should be considered when implementing DOE in Quality By Design.

Publication: BioProcess International

Published: March 2010
Author: Mark Anderson

To accelerate their product development, Z Corporation tooled up their engineers with the knowledge and software to do statistical design of experiments (DOE). The company developed a procedure by which every factor with a reasonable chance of affecting product performance is systematically and simultaneously evaluated via these controlled experiments.

Published: March 2010
Author: DE Editors

To accelerate their product development, Z Corporation tooled up their engineers with the knowledge and software to do statistical design of experiments (DOE). The company developed a procedure by which every factor with a reasonable chance of affecting product performance is systematically and simultaneously evaluated via these controlled experiments.

Publication: Digital Engineering

Published: January 2010
Authors: Ian Forster, Warren Dominy, Addison Lawrence, Frank Castille, Susmita Patnaik

Two five-week growth trials were conducted using mixture methodology to optimize a reference diet for Pacific white shrimp using krill meal, menhaden fishmeal, squid meal, and soy protein isolate (SPI).

Publication: Aquaculture

Published: January 2010
Authors: A. Marino, R. Fauci, R. Donelli, A. Schettino

Design of Experiments was used to study the laminar-turbulence transition phenomenon in a Hypersonic regime on a 3-deg half-angle sphere-cone model.

Publication: SixSigmaIn Team

Published: September 2009
Authors: Drissand Elhanafi, Jim Carey

DOE was used to determine the statistically significant factors affecting the growth of an E. coli cell line in shaker flasks.

Publication: NCSU Bioprocessing and Process Development Symposium

Design of Experiments Helps Optimize Cell Culture Bioproduction System

Published: August 2009

To handle numerous variables Invitrogen Corporation utilized design of experiments (DOE) methods to reveal a complicated array of multi-factor interactions involved in bioprocess development.

Publication: BioProcess International

Making Use of Mixture Design to Optimize Olive Oil - A Case Study

Published: August 2009
Authors: Mark Anderson, Patrick Whitcomb

Olive oil, an important commodity of the Mediterranean region and a main ingredient of their world-renowned diet (see sidebar), must meet stringent European guidelines to achieve the coveted status of "extra virgin." Oils made from single cultivars (a particular cultivated variety of the olive tree) will at times fall into the lower "virgin" category due to seasonal variation. Then it becomes advantageous to blend in one or more superior oils based on a mixture design for optimal formulation.

Publication: ASQ Chemical and Process Industries Division Newsletter

Published: July 2009
Author: Henkel Corp.

An agricultural equipment manufacturer asked Henkel to help optimize a tough coating application using DOE.

Publication: SAE Off-Highway Engineering

Published: June 2009
Author: Land O'Lakes

Using design of experiments, Land O'Lakes researchers set out to improve a new deli process cheese formulation, without impacting its other attributes.

Publication: Food Product Design