Case Studies and White Papers


Published: September 2010
Authors: Mark Anderson, Patrick Whitcomb

The statistical design of experiments is an essential ingredient of successful product development and improvement, and provides an efficient and scientific approach to obtaining meaningful information. In contrast to traditional vary one-factor-at-a-time (OFAT) experimentation, variables are changed together, permitting evaluation of interactions. Standard texts give details about the construction of specific test plans, such full and fractional factorial, and response surface designs, and the analysis of the resulting data. This article gives a brief overview. The focus here is on the fundamental elements of experimental design: defining the purpose and scope of the experiment, differentiating between alternative types of experimental variables, understanding the underlying environment and constraints, and conducting stage-wise experimentation. Brief discussions dealing with the statistical analysis tools, multiple response variables, and some historical background are also provided.

Publication: Kirk-Othmer Encyclopedia of Chemical Technology

Published: July 2010

Schiff Nutrition used DOE to solve an intermittent problem with a multimineral tablet sticking inside the dies of a high-speed rotary tablet press. (To see the figures, download the manuscript from link below.)

Publication: Healthcare Packaging

Published: June 2010
Authors: Mahesh Shivhare, Graham McCreath

This article details the role DOE in achieving Quality by Design (QbD) for the manufacture of active pharmaceutical ingredients (API). It features outputs from Design-Expert, the author's top choice for DOE software.

Publication: BioProcess International

Published: June 2010
Author: Dresser Waukesha

The Dresser Waukesha development team adopted the design of experiments (DOE) approach to increase the accuracy of performance estimates and reduce the number of required tests.

Publication: Power

Published: March 2010
Author: DE Editors

To accelerate their product development, Z Corporation tooled up their engineers with the knowledge and software to do statistical design of experiments (DOE). The company developed a procedure by which every factor with a reasonable chance of affecting product performance is systematically and simultaneously evaluated via these controlled experiments.

Publication: Digital Engineering

Published: March 2010
Author: Mark Anderson

To accelerate their product development, Z Corporation tooled up their engineers with the knowledge and software to do statistical design of experiments (DOE). The company developed a procedure by which every factor with a reasonable chance of affecting product performance is systematically and simultaneously evaluated via these controlled experiments.

Published: January 2010
Authors: A. Marino, R. Fauci, R. Donelli, A. Schettino

Design of Experiments was used to study the laminar-turbulence transition phenomenon in a Hypersonic regime on a 3-deg half-angle sphere-cone model.

Publication: SixSigmaIn Team

Published: January 2010
Authors: Ian Forster, Warren Dominy, Addison Lawrence, Frank Castille, Susmita Patnaik

Two five-week growth trials were conducted using mixture methodology to optimize a reference diet for Pacific white shrimp using krill meal, menhaden fishmeal, squid meal, and soy protein isolate (SPI).

Publication: Aquaculture

Published: September 2009
Authors: Drissand Elhanafi, Jim Carey

Aided by DOE, biochemists determined the statistically significant factors affecting the growth of an E. coli cell line in shaker flasks.

Publication: NCSU Bioprocessing and Process Development Symposium

Design of Experiments Helps Optimize Cell Culture Bioproduction System

Published: August 2009

Invitrogen Corporation utilized response surface methods (RSM) to reveal a complicated array of multi-factor interactions involved in bioprocess development. Using advanced tools in Design-Expert, they achieved more desirable conditions in a minimal number of runs.

Publication: BioProcess International