Case Studies

Items 31 to 45 of 205 total

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  1. Fed-Batch Cell Culture Process Optimization

    March 2012

    Researchers aiming to upgrade a fed-batch process observed that basal and feed media have interrelated impacts on process outcomes (a pairing effect). They did a DOE enabled by Design-Expert software for fed-batch cell culture process optimization.

    Authors: Jiang, Droms, Geng, Casnocha,
    Publication: BioProcess International
  2. Using DOE with Tolerance Intervals to Verify Specifications

    March 2012

    Statistical methods are becoming increasingly vital for pharmaceutical manufacturers. Design of experiments (DOE) is a primary tool for determining the relationship between the factors that have an effect on a process and the response of that process.

    Authors: Whitcomb, Patrick J., Anderson, Mark J.
    Publication: Stat-Ease, Inc.
  3. Widespread suppression of huntingtin with convection-enhanced delivery of siRNA

    January 2012

    This article explores a therapeutic strategy for treating Huntington's disease.

    Authors: Stiles, Zhang, Ge, Nelson, Grondin, Ai, Hardy, Nelson, Guzaev, Butt, Charisse, Kosovrasti, Tchangov, Meys, Maier, Nechev, Manoharan, Kaemmerer, Gwost, Stewart, Gash, Sah
    Publication: Pharma Qbd
  4. DOE It Yourself

    November 2011

    Fun science projects

    Authors: Anderson, Mark J.
    Publication: Stat-Ease, Inc.
  5. Sensory and Chemical Characteristics of Worts Fermented by Leuconostoc citreum and Saccharomyces cerevisiae and Consumer Acceptability with Added Flavorings

    November 2011

    This study was conducted to examine the chemical and sensory characteristics of fermented worts and consumer acceptability according to added flavorings.

    Authors: Shin, Delgerzaya, Lim, Park, Kim
    Publication: Food Science & Biotechnology
  6. Design of Experiments for Non-Manufacturing Processes: Benefits, Challenges, and Some Examples

    November 2011
    Design of experiments (DOE) is a powerful technique for process optimization that has been widely deployed in almost all types of manufacturing processes and is used extensively in product process design and development.
    Authors: Anderson, Mark J.; Antony, Jiju; Coleman, Shirley Y.; Johnson, Rachel T.; Montgomery, Douglas C.
    Publication: Procedings of the Institution of Mechanical Engineers, Part B: Journal of Engineering Manufacture
  7. Design-Expert Diagnostics Saves Experiment (and Post-Grad Student)

    August 2011

    Design-Expert's features for checking design properties including diagnostics helped a student achieve a valid analysis

    Authors: Mullenix, Paul
    Publication:
  8. Two-step optimization for product design takes manufacturing variability into account

    July 2011

    The TRW team used a combination of DOE (response surface methodology RSM) and Monte Carlo analysis to optimize a braking system where one of the objectives was to quickly generate pressure when demanded by the vehicle stability control system.

    Authors: TRW
    Publication: Digital Engineering
  9. Software for Fine-Tuning Flotation Cells

    April 2011

    FLSmidth recently installed two turnkey SuperCell flotation machines the world's largest flotation cells at Rio Tinto's Kennecott Utah Copper concentrator near Salt Lake City, Utah. They used DOE to substantially reduce the amount of testing and fine-tuning required after installation.

    Authors: F. L. Smidth
    Publication: E&MJ Engineering & Mining Journal
  10. Use of the Design of Experiments to Develop a Scalable Route to a Key Chirally Pure Arylpiperazine

    March 2011

    In this presentation design of experiments (DOE) was applied to a chemical process. DOE together with computer modeling lead to a better understanding of the process and the defining of new conditions.

    Authors: Aptuit
    Publication:
  11. Design of Experiments Helps Optimize Injection Molding of Conductive Compounds

    March 2011

    When performing experiments on surface conductivity, a material supplier used DOE software to get answers quicker and more efficiently

    Authors: RTP Co.
    Publication: Injection Molding/Plastics Today
  12. Innovative Solutions for Efficient Lamps: Mixture Optimization Using a DOE Approach

    March 2011

    DOE was used to determine the optimum setting conditions for three components leading to a high Hg Yield at a lower temperature.

    Authors: SAES Group
    Publication:
  13. What to look for in Statistical Software for the Pharmaceutical Industry

    January 2011

    This article discusses what to look for in DOE software in the pharmaceutical industry.

    Authors: Anderson, Mark J.
    Publication: Pharmaceutical Manufacturing
  14. Automated Optimization of Murine Embryonic Stem Cell Differentiation into Cardiomyocytes

    January 2011

    Pure populations of cardiomyocytes derived from embryonic stem cells offer great promise as potential cell replacement therapies, as well as for use in pharmaceutical studies. The differentiation process, however, is frequently inefficient and nonspecific. We sought to improve upon the current processes by coupling automation and Design of Experiment (DOE). DOEgenerated combinations of pro-cardiomyocyte compounds were converted to dispensing volumes using Automated Assay Optimization (AAO) for BioRAPTR* software, and reagents and cells were dispensed into 384-well plates using the BioRAPTR FRD* Microfluidic Workstation. After five days of culture, the resulting embryoid bodies (EBs) were transferred to 96-well gelatin-coated plates using the Biomek FXP* liquid handler. Over an additional three days, the wells were observed for spontaneously beating regions of cardiomyocytes, and the differentiated cells were further analyzed using flow cytometry to detect myosin heavy chain as a marker of cardiomyocytes. This bulletin illustrates the potential of a system that can both automate and optimize the differentiation of murine embryonic stem cells.

    Authors: Kowalski, Liu, Yoder, Pajak
    Publication: Beckman Coulter
  15. White Paper on Optimal Design Tools

    December 2010
    Our new version of Design-Expert now offers additional optimal design options not just D-optimal.
    Authors: Anderson, Mark J.
    Publication: Stat-Ease Inc.

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