Case Studies

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  1. Technology for Corn Ethanol Measurement

    August 2018
    In this application, a supplier of industrial equipment wanted to market an existing product to companies producing ethanol from corn. There was anecdotal evidence indicating that the device increased ethanol yield. However, prior to marketing the device the company wanted to find the best operating conditions and determine what performance ethanol producers could expect from the product. The industrial equipment supplier contracted with SALLC to develop a method for measuring how well the supplier’s product improved performance to the corn ethanol market.
    Authors: Jerry Fireman
    Publication: Laboratory Focus
  2. DOE, HPLC Validate Corn Ethanol Measurement Technology

    February 2018
    Mark Anderson, Stat-Ease Principal, discusses how an industrial equipment supplier made great improvements to their corn ethanol measurement process using DOE and HPLC methods.
    Authors: Mark Anderson
    Publication: Laboratory Equipment
  3. Design of Experiments Improves Peptide Bond Yield from 20% to 76%

    February 2018

    Researchers worked to fine-tune the conditions that best promote peptide bond formation in an uncatalyzed aqueous phase reaction. We felt that we should be able to obtain a better yield than our initial 20% and had a hunch that one or more interactions between variables might be playing a role that was obscured by the OFAT method.

    Authors: Professor Palwinder Singh & Dr. Manpreet Singh Bhatti
    Publication: Laboratory Focus
  4. Design of Experiment Reduces Development Time for Higher-Performing Metal-Cutting Fluids

    January 2018
    The large number of interactive ingredients makes developing metalworking fluids (MWFs) a complex process. Design of Experiment (DOE) methodology recently helped chemists develop an MWF using half the number of formulations typically necessary. The DOE software accurately projected that the emulsion stability of the optimized formulation would be substantially better than the current product.
    Authors: David Slinkman and Yixing (Philip) Zhao
    Publication: Tribology & Lubrication Technology
  5. Design of Experiments Improves Throughput of Key Intermediate

    December 2017
    This article explains how Codexis developed the manufacturing process for (2S, 3R)-Epoxide (1), a key intermediate used in the production of Atazanavir (marketed as Reyataz), an antiretroviral drug used to treat human immunodeficiency virus (HIV).
    Authors: Jerry Fireman
    Publication: Express Pharma
  6. In Pursuit of Optimal Weld Parameters - The How To -

    December 2014

    This article offers a five-step method to finding the optimum or ‘best’ weld. The method detailed below utilizes a statistical tool known as the two-level factor approach. This well-tested method will assist an investigator in identifying what is to be optimized, choosing inputs for evaluation, running the tests so that statistically significant data is generated, analyzing data, and finally determining the settings for the significant inputs which result in the optimum weld.

    Authors: Chris Bertoni
    Publication: Welding Design & Fabrication
  7. Practical Aspects for Designing Statistically Optimal Experiments

    March 2014
    Due to operational or physical considerations, standard factorial and response surface method (RSM) design of experiments (DOE) often prove to be unsuitable. In such cases a computer-generated statistically-optimal design fills the breech. This article explores vital mathematical properties for evaluating alternative designs with a focus on what is really important for industrial experimenters. To assess “goodness of design” such evaluations must consider the model choice, specific optimality criteria (in particular D and I), precision of estimation based on the fraction of design space (FDS), the number of runs to achieve required precision, lack-of-fit testing, and so forth. With a focus on RSM, all these issues are considered at a practical level, keeping engineers and scientists in mind. This brings to the forefront such considerations as subject-matter knowledge from first principles and experience, factor choice and the feasibility of the experiment design.
    Authors: Anderson, Mark J.; Whitcomb, Patrick J.
    Publication: Journal of Statistical Science and Application V2, N3, March, pp 85-92
  8. Improved Copper and Gold Recovery at KGHM International’s Robinson Mine

    January 2014

    In an effort to recover additional copper and gold at KGHM International’s Robinson Mine located near Ruth, Nevada, an in-plant study was undertaken to quantify potential flotation recoveries from the concentrator’s final tailings stream. Tests were conducted by passing a small continuous sample of final tailings through a single 1.5 m3 FLSmidth XCELL™ demonstration flotation machine. This paper reviews the results obtained from the in-plant testing with the single 1.5 m3 flotation cell and provides a comparison to the subsequent operational performance of multiple 160 m3 flotation machines

    Authors: Redden, Lorin; Stevens,Chase; O’Brien, Mark; and Bender, Thomas
    Publication:
  9. DOE Improves Throughput in Manufacturing of Key Intermediate

    July 2013

    Researchers improved the performance of an isolated ketoreductase (KRED) enzyme using directed evolution, and also performed two stages of design of experiments (DOE) to identify and optimize key process variables.

    Authors: Collier, Ph.D., Steve
    Publication: Pharmaceutical Manufacturing
  10. Design of Experiments Helps Increase Yield of Pharmaceutical Intermediate from 70% to 88%

    May 2012

    Researchers at Codexis Laboratories Singapore performed a full-factorial designed experiment with 20 runs to determine the impact of four independent variables on product selectivity during a silylation reaction. The result was a process that delivered 95% selectivity along with an 88% yield

    Authors: Collier, Wilson
    Publication: Pharmaceutical Manufacturing
  11. Framing a QbD Design Space with Tolerance Intervals

    May 2012

    Given the push for Quality by Design by FDA and agencies worldwide, statistical methods are becoming increasingly vital for pharmaceutical manufacturers. DOE is used to determine the impact of multiple factors and their interaction.

    Authors: Anderson, Mark J.
    Publication: Pharma Qbd
  12. Sensory and Chemical Characteristics of Worts Fermented by Leuconostoc citreum and Saccharomyces cerevisiae and Consumer Acceptability with Added Flavorings

    November 2011

    This study was conducted to examine the chemical and sensory characteristics of fermented worts and consumer acceptability according to added flavorings.

    Authors: Shin, Delgerzaya, Lim, Park, Kim
    Publication: Food Science & Biotechnology
  13. Use of the Design of Experiments to Develop a Scalable Route to a Key Chirally Pure Arylpiperazine

    March 2011

    In this presentation design of experiments (DOE) was applied to a chemical process. DOE together with computer modeling lead to a better understanding of the process and the defining of new conditions.

    Authors: Aptuit
    Publication:
  14. Design of Experiments Helps Optimize Injection Molding of Conductive Compounds

    March 2011

    When performing experiments on surface conductivity, a material supplier used DOE software to get answers quicker and more efficiently

    Authors: RTP Co.
    Publication: Injection Molding/Plastics Today
  15. Design of Experiments Helps Z Corporation Develop Unique 3D Color Printers

    March 2010
    To accelerate their product development, Z Corporation tooled up their engineers with the knowledge and software to do statistical design of experiments (DOE). The company developed a procedure by which every factor with a reasonable chance of affecting product performance is systematically and simultaneously evaluated via these controlled experiments.
    Authors:
    Publication:

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