This tutorial details how Design-Expert^{®} software crafts a response
surface method (RSM) experiment within an irregular process space. If you are in
a hurry to learn only the bare essentials of computer-based optimal design, then
bypass the **Note** sections. However, they are well worth the time spent to
explore things.

A food scientist wants to optimize a wheat product cooked at varying times versus temperatures. After a series of screening and in-depth factorial designs, the search for a process optimum has been narrowed to two factors, ranging as follows:

- Temperature, 110 to 180 degrees C.
- Time, 17 to 23 minutes.

However, it’s been discovered that to initiate desirable starch gelatinization, time must be at least 19 minutes when temperature is at 110°C—the low end of its experimental range. On the other hand, when the temperature is increased to 180°C the starch will gel in only 17 minutes.

To recap: At the lowest level of A, factor B must be at least 19, while at the lowest level of B, factor A must be at least 180. To complicate matters further, the experimenter suspects that the response surface may be wavy. That is, the standard quadratic model used for response surface methods (RSM) may fall short for providing accurate predictions. Therefore, a cubic model is recommended for the design.

A problem like this can be handled by Design-Expert via its constraint tools and optimal design capability.

Start Design-Expert and initiate the design process by clicking the blank-sheet icon on the left of the toolbar.

Under **Standard Designs** click **Response Surface** to expand its menu. Select
**Optimal (custom)** as the design, and enter the **L[1]** (lower) and **L[2]**
(upper) limits as shown below.

Press the **Edit Constraints** button under the table.

At this stage, if you know the multilinear constraint(s), you can enter them directly by doing some math.

Note

Multifactor constraints must be entered as an equation taking the
form of: βL ≤ β1A+ β1B…≤ βU, where βL and βU are lower and upper limits,
respectively. Anderson and Whitcomb provide guidelines for developing
constraint equations in Appendix 7A of their book *RSM Simplified*. If, as in
this case for both A and B, you want factors to exceed their constraint points
(CP), this equation describes the boundary for the experimental region:

\(1\leq \frac{A-LL_A}{CP_A - LL_A} + \frac{B-LL_B}{CP_B-LL_B}\)

where LL is the lower level. In this case, lower levels are 110 for factor A and 17 for factor B. These factors’ CPs are 180 for factor A and 19 for factor B (the endpoints on the diagonal constraint line shown in the figure below).

Plugging in these values produces this equation:

\(1\leq \frac{A-110}{180-110} + \frac{B-17}{19-17}\)

However, the software requires formatting as a linear equation. This is accomplished using simple arithmetic as shown below.

\(1\leq \frac{A-110}{70} + \frac{B-17}{2}\)

\((70)(2)(1)\leq 2(A-110)+70(B-17)\)

\(140\leq 2A-220+70B-1190\)

\(1550\leq 2A+70B\)

Dividing both sides by 2 simplifies the equation to \(775\leq A + 35B\) . This last equation can be entered directly, or it can be derived by Design-Expert from the constraint points while setting up a RSM design.

Rather than entering this in directly, let’s make Design-Expert do the math.
Click the **Add Constraint Tool** button. It’s already set up with the appropriate
defaults based on what you’ve entered so far for the design constraints.

As directed by the on-screen instructions, start by specifying the combination,
or **Vertex** in geometric terminology, that must be excluded – shown in red
below

Double-click the cell for vertex **A** and select **110** from the drop-down
menu.

Then change the Vertex coordinate for **B** to **17**.

The next step indicated by the instructions is to enter in the **Constraint
Point** field the level for **B** (time) which becomes feasible when the
temperature is at its low level of 110. Enter **19** – the time need at a minimum
to initiate gelatinization of the starch.

Notice that Design-Expert correctly changed the inequality to greater than (>).

Now we turn our attention back to factor **A** (temperature) and its **Constraint
Point**. It must be at least **180** when B (time) is at its vertex (low) level.

Notice that Design-Expert changed the inequality to greater than (>), which is correct.

Press **OK** to see that Design-Expert calculated the same multilinear constraint
equation that we derived mathematically.

Press **OK** to accept this inequality constraint. Then press **Next**.

Leave the Search option default of “Best” and Optimality on the “I” criterion.

Note

Take a moment now to read the helpful information provided on screen, which provides some pros and cons to these defaults. Note that we recommend I-optimality for response surface designs like this. Press screen tips (light-bulb icon) for more details about the “Optimal Model Selection Screen.” Feel free to click the link that explains how Design-Expert uses the “Best” search from coordinate and point exchange.

Press the **Edit Model** button to upgrade the default model of quadratic to Cubic.
(Recall that the experimenter suspects the response might be ‘wavy’ — a surface
that may not get fit adequately with only the default quadratic model.)

The defaults for the runs are a bit more than the experimenter would like to run
for lack of fit and replicates. To limit the number of runs, change the **Lack of
fit points** — from 5 (by default) to **4**. Also decrease the **Replicates** to
**4**. The experimenter realizes this will decrease the robustness of the design,
but decides that runs are too costly, so they need to be limited.

Press **Next** to go to the response entry — leave this at the generic default of
“R1” (we will not look at the experimental results). Then **Finish** on to build
the optimal design for the constrained process space.

Note

At this stage, Design-Expert randomly chooses a set of design points called the “bootstrap.” It then repeatedly exchanges alternative points until achieving a set that meets the specifications established in the model selection screen.

Because of the random bootstraps, design builds vary, but all will be essentially (for all practical purposes) as optimal. Then to see the selection of points:

- right-click the
Select(top left cell) button and pickDesign ID,- right-click the header for the
Idcolumn andSort Ascending,- right-click the
Selectbutton and click on theSpace Point Type.

You should now see a list of design points that are identified and sorted by their geometry. Due to the random bootstraps, your points may vary from those shown below.

Note

Look over the design and, in particular, the point types labeled as “vertex”: Is the combination of (110, 17) for (A,B) excluded? It should be – this is too low a temperature and too short a time for the starch to gel.

P.S. To see how Design-Expert built your design, click the **Summary** node under
the **Design** branch.

To accurately assess whether these combinations of factors provide sufficient
information to fit a cubic model, click the design **Evaluation** node.

Based on the design specification, the program automatically chooses the cubic
order for evaluation. Press **Results** to see how well it designed the
experiment.

No aliases are found: That’s a good start! However, you may be surprised at the low power statistics and how they vary by term. This is fairly typical for designs with multilinear constraints. Therefore, we recommend you use the fraction of design space (FDS) graph as an alternative for assessing the sizing of such experiments. This will come up in just a moment.

Press the **Graphs** tab. Let’s assume that the experimenter hopes to see
differences as small as two standard deviations in the response, in other words
a signal-to-noise ratio of 2. In the **FDS tool** on the left enter a **d** of
**2**. Press the Tab key to see the fraction of design space that achieves this
level of precision for prediction (“d” signifying the response difference) given
the standard deviation (“s”) of 1.

Ideally the FDS, reported in the legend at the left of the graph, will be 0.8 or more as it is in this case. This design is good to go!

Note

A great deal of information on FDS is available at your fingertips via the screen tips. Take a look at this and click the link to the “FDS Graph Tool.” Exit out of the screen-tips help screen when finished.

On the **Graphs Toolbar** press **Contour** to see where your points are located
(expect these to differ somewhat from those shown below).

Our points appear to be well-spaced and the choices for replication (points
labeled “2”) seem reasonable. Select **View**, **3D Surface** (or choose this off
the Graphs Toolbar) to see the surface for standard error.

This design produces a relatively flat surface on the standard error plot, that is, it provides very similar precision for predictions throughout the experimental region.

This concludes the tutorial on optimal design for response surface methods.

Note

You are now on your own. Depending on which points Design-Expert picked for your design, you may want to add a few more runs* at the extreme vertices, along an edge, or in other locations to decrease relatively high prediction variances. If you modify the design, go back and evaluate it. Check the 3D view of standard error and see how much lower it becomes at the point(s) you add. In any case, you can rest assured that, via its optimal design capability, Design-Expert will provide a good spread of processing conditions to fit the model that you specify, and do it within the feasible region dictated by you.

*We detailed how to modify the design layout in Part 2 of General One-Factor Tutorial (Advanced Features).