Advanced Formulations: Combining Mixture & Process Variables (2 Days)

Day 1	Section 1—Review Exercises (process)
	Factorial  (mouse cell) Sizing for power RSM  (extruder) Multiple linear constraints (MLCs) Sizing for precision with FDS Optimal design Spray coating exercise
	Section 2—Mixture Review and Optimization
	Mixture (hydrophilic tablet) Build and analyze Numeric Optimization Graphical Optimization Propagation of error
Lunch	Section 3—Combining Mixture and Process Variables
	User defined crossed designs  (fish) D-optimal crossed designs  (fish & cure time) Mixture amount experiments  (hormones) Mixtures with categoric factors  (auto coating)
Day 2	Section 4—Combining Mixture Designs
	Combining two mixtures (nutrient solution) Balancing cations and anions Lady Baltimore (two mixtures and an amount) Model reduction via combined order
	Section 5—Using Ratios of Components
	Ratios as a natural scale  (gasoline blending) Using log ratios  (polymer formulation) Using ratios to combine designs Combining mixtures Combining mixture and process
Lunch	Section 6—Specialized Mixture Topics
	Partial Quadratic Mixture (PQM) models Linear with select squared and cross product terms Linear + squared terms  (screening) An additional equality constraint  (coating) Inverted simplex  U_Pseudo Selecting a metric for components  (polyols)
	Section 7—Review Exercises (as time allows)
	Homework assignment DOE support Review material (as time allows): Augmenting a mixture design  (sparklers) Sizing designs to detect a difference  (paint verification)
	Section 8—Appendix (reference only)
	Quartic and special quartic models Cox’s mixture models Slack variable models

See the public workshop schedule and the Advanced Formulation course description for further information on this class.