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Day 1
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Section 1—Introduction to Factorial Design |
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- Brief description of factorial design
- The factorial design planning process
- Basics of factorial design (microwave popcorn)
- Multiple response optimization
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| Lunch |
Section 2—Enhancements for Full Factorials |
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- Replicated full factorial (mouse cell assay)
- 28 full factorial (assay contaminants)
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Section 3a—Fractional Factorials |
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- Fractional factorials
- 28-2 fractional factorial (assay contaminants)
- Setup and aliases
- Minimum-run resolution V (MR5) designs (stent delivery)
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| Day 2 |
Section 3b—General Factorials |
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- Immunofluorescent assay optimization
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Section 4—Introduction to Response Surface Design |
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- Factorial with center points (bench reaction)
- Introducing Response Surface Methods “RSM”
- Augmenting to central composite design “CCD”
- “Good” response surface designs
- Sizing for precision
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Section 5—Response Surface Methodology |
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- Instructor led exercise (fluid bed coating)
- Building the design
- Details of analysis
- Optimization
- Quality by Design “QbD”
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| Lunch |
Section 6—Constrained Response Surface |
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- Constrained design space
- Optimal design
- Stent spray coating
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Section 7—Quality by Design "QbD" |
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- Quality by Design
- Illustrative example (tableting process)
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Section 8—Introduction to Mixture Design |
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- What makes a mixture?
- Mixture (Scheffé) polynomials
- Simplex lattice designs (synthetic medium)
- Constrained mixture (antiseptic)
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Summary |
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